Karlee remains a top-tier Cleaner due to her innate ability to sense dangers, an extra quick slot, and significant team use speed. For 2025, her builds focus on amplifying these core strengths while adapting to evolving threats.
The Sentinel Support Build
This build enhances Karlee's awareness and team utility, making her invaluable for spotting threats and providing rapid assistance.

Core Focus:
- Hazard Detection & Mitigation
- Team Support & Revives
- Objective Interaction Speed
Key Card Synergies (Tier 1-4):

- Enhanced Senses: Cards that further increase hazard detection range or highlight special Ridden for longer durations.
- Use Speed Stacking: Combine Karlee's base Use Speed with cards like "Headband Magnifier" and "Multitool" for near-instant interactions.
- Medical Professional: Cards such as "Combat Medic," "Experienced EMT," and "Field Surgeon" to maximize revive speed and healing efficiency.
- Utility Scavenger / Offensive Scavenger: To ensure a steady supply of support and offensive items for the team, leveraging her extra quick slot.
- Needs of the Many / Guardian Angel: Team-focused defensive cards that synergize well with a support role.
Weapon Choice:
Assault Rifles or SMGs for versatility. A high-capacity sidearm is recommended.
Gameplay:

Stay central to the team, call out threats, prioritize reviving teammates, and use your speed to quickly complete objectives or disarm traps.
Rapid Objective Specialist Build
Designed for speed and efficiency, this build allows Karlee to quickly navigate maps, complete objectives, and escape dangerous situations.
Core Focus:

- Movement Speed & Stamina
- Objective Rush
- Solo Survivability
Key Card Synergies (Tier 1-4):
- Mobility Suite: "Run Like Hell," "Cross Trainers," "Fleet of Foot," and "Mad Dash" are essential for maximum map traversal.
- Stamina Regeneration: Cards that boost stamina recovery to maintain sprint uptime.
- Use Speed for Objectives: Even with a speed focus, cards enhancing Use Speed for key interactions are vital.
- Evasive Maneuvers: Cards like "Breakout" or those offering temporary damage resistance after sprinting or taking hits.
- On Your Mark...: For team-wide speed boosts after clearing hordes, facilitating faster progression.
Weapon Choice:

Lightweight SMGs or shotguns (for close-quarters clearing). Melee weapon for stamina-free Ridden clearing.
Gameplay:
Lead the charge on objectives, utilizing Karlee's Use Speed and hazard detection to identify safe paths. Focus on kiting and avoiding unnecessary fights.
Master Scavenger & Technician Build
This build maximizes Karlee's ability to find and utilize items, turning her into a resource-generating powerhouse for the team, especially with her starting Toolkit.

Core Focus:
- Item Generation & Efficiency
- Quick Item Specialization
- Trap Disarming & Locked Door Access
Key Card Synergies (Tier 1-4):

- Scavenger Cards: "Copper Scavenger," "Weapon Scavenger," "Utility Scavenger," and "Offensive Scavenger" are foundational.
- Quick Item Enhancements: "Tool Belts" for more slots, "Surplus Pouches" for team benefits, and cards improving specific quick item types (e.g., "Bomb Squad").
- Lucky Pennies / Compound Interest: To maximize copper gain for team upgrades.
- Magician's Apprentice: Chance to reuse quick items, further boosting resource efficiency.
- Anything that boosts Toolkit effectiveness or provides additional Toolkits.
Weapon Choice:
Flexible, but consider weapons with good ammo efficiency to conserve resources. Her starting TEC 9 remains a solid early-game option.
Gameplay:

Thoroughly search areas for supplies, manage team resources effectively, and be the primary disarmer and door-opener. Utilize offensive items generously due to increased availability.